THE INFLUENCE OF ANION PENETRATING ABILITY ON URINARlY ACIDIFICATION AND THE EXCRETION
نویسنده
چکیده
IPrevious studies in the dog have demonstrated that during administration of neutral sodium phosphate the rate of titratable acid excretion is directly proportional to the rate of phosphate excretion and is inversely related to plasma bicarbonate concentration (1). Markedly acid urines containing near theoretical maximum amounts of titratable acid 1 were observed only in the presence of severe metabolic acidosis. More recently it has been shown that intense acidification of the urine can be achieved without the induction of acidosis (2). Normal subjects stimulated to retain sodium showed a rapid fall in urine pH to approximately 5.0 or below when infused with sodium sulfate, and it was concluded that increased reabsorption of sodium in the presence of a poorly reabsorbable anion was responsible for this phenomlenon. Acidification of the urine has also been observed during administration of poorly reabsorbable anions to normal human subjects during quiet standing (3) and to dogs in which glomerular filtration rate was reduced by clamping of the renal artery (4)-experimental procedures known to induce a more complete reabsorption of filtered sodium. These observations raise the possibility that, even without acidosis, large numbers of hydrogen ions might be transported into the glomerular filtrate over a
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